4-[1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol and tamoxifen

4-[1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol has been researched along with tamoxifen in 36 studies

Research

Studies (36)

Timeframe	Studies, this research(%)	All Research%
pre-1990	3 (8.33)	18.7374
1990's	8 (22.22)	18.2507
2000's	8 (22.22)	29.6817
2010's	17 (47.22)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Edwards, KJ; Laughton, CA; Neidle, S	1
Bignon, E; Crastes de Paulet, A; Doré, JC; Gilbert, J; Miquel, JF; Ojasoo, T; Pons, M; Raynaud, JP	1
Blackburn, GM; Foster, AB; Goodman, J; Jarman, M; Leclercq, G; Legros, N; McCague, R	1
Abecassis, J; Bignon, E; Crastes de Paulet, AC; Doré, JC; Gilbert, J; Miquel, JF; Ojasoo, T; Pons, M; Raynaud, JP	1
Devleeschouwer, N; Foster, AB; Jarman, M; Leclercq, G; Leung, OT; McCague, R	1
Edwards, KJ; Hardcastle, IR; Houghton, J; Jarman, M; Laughton, CA; Neidle, S; Parr, IB; Potter, GA; Rowlands, MG; Trent, JO	1
Adrian, MD; Bryant, HU; Cho, S; Cole, HW; Finley, DR; Glasebrook, AL; Godfrey, AG; Grese, TA; Jones, CD; Lugar, CW; Magee, DE; Martin, MJ; Matsumoto, K; Pennington, LD; Phillips, DL; Rowley, ER; Short, LL; Winter, MA	1
Doré, JC; Fuentes, M; Gilbert, J; Ojasoo, T; Pons, M	1
Bryant, HU; Cullinan, GJ; Glasebrook, AL; Hauser, KL; Muehl, BS; Palkowitz, AD; Pell, TR; Phillips, DL; Sato, M; Shetler, PK; Short, LL; Thrasher, KJ	1
Bélanger, A; Caron, B; Cloutier, J; Dory, YL; Favre, A; Gauthier, S; Labrie, C; Labrie, F; Larouche, D; Leblanc, G; Mailhot, J; Martel, C; Mérand, Y; Ouellet, C; Schwerdtfeger, A; Simard, J	1
Adrian, MD; Bryant, HU; Cole, HW; Fuson, TR; Glasebrook, AL; Grese, TA; Magee, DE; Pennington, LD; Phillips, DL; Rowley, ER; Sato, M; Shetler, PK; Short, LL; Sluka, JP; Venugopalan, M; Yang, NN	1
Bachmann, H; Gust, R; Lubczyk, V	1
Bischoff, SF; Buhl, T; Floersheim, P; Fournier, B; Halleux, C; Kallen, J; Keller, H; Renaud, J; Schlaeppi, JM; Stark, W	1
Bekaii-Saab, TS; Greenblatt, DJ; Perloff, MD; von Moltke, LL; Weemhoff, JL	1
Ernst, B; Lill, MA; Vedani, A; Winiger, F	1
Gao, M; Miller, KD; Sledge, GW; Wang, M; Zheng, QH	1
Artemenko, N; Barrett, I; Carr, M; Golfis, G; Hughes, RB; Knox, AJ; Lloyd, DG; Meegan, MJ; Zisterer, DM	1
Armstrong, MD; Arteaga, CL; Brown, HA; Buck, JR; Cho, HP; Criswell, TL; Lindsley, CW; Scott, SA; Selvy, PE; Thomas, AL	1
Bellavance, E; Luu-The, V; Poirier, D	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Dettmann, S; Gust, R; Müller, CE; Schiedel, A; Szymanowitz, K; Wellner, A	1
Bhatnagar, D; Boue, SM; Burow, ME; Collins-Burow, BM; Driver, J; Elliott, S; Jiang, Q; McLachlan, JA; Payton-Stewart, F; Rhodes, LV; Sridhar, J; Stevens, C; Wang, G; Wiese, TE; Zhang, Q; Zheng, S	1
Bearss, NR; Bhatnagar, D; Boue, SM; Burow, ME; Cleveland, TE; Erhardt, PW; Khupse, RS; Reese, MD; Sarver, JG; Trendel, JA; Wiese, TE	1
Bourassa, P; Dubeau, S; Fauq, AH; Maharvi, GM; Tajmir-Riahi, HA; Thomas, TJ	1
Bryant, HU; Chalmers, MJ; Dodge, JA; Griffin, PR; Montrose-Rafizdeh, C; Novick, S; Sato, M; Wang, Y	1
D'Agostino, J; Hollenberg, PF; Sridar, C	1
Christodoulou, MS; Dalla Via, L; Fokialakis, N; García-Argáez, AN; Gia, OM; Haroutounian, SA; Passarella, D; Pongratz, I	1
Jiang, Q; Wang, G; Zhang, Q; Zheng, S; Zhong, Q	1
Chiba, Y; Endo, Y; Kaise, A; Ohta, K	1
Aparicio, A; Bonnefous, C; Brigham, D; Darimont, B; Douglas, K; Govek, S; Grillot, K; Hager, JH; Heyman, R; Joseph, JD; Julien, J; Kahraman, M; Kaufman, J; Lai, A; Lee, KJ; Lu, N; Moon, MJ; Nagasawa, J; Prudente, R; Qian, J; Rix, PJ; Sensintaffar, J; Shao, G; Smith, ND	1
Andrews, DM; Ballard, P; Bradbury, RH; Buttar, D; Callis, RJ; Currie, GS; Curwen, JO; Davies, CD; de Almeida, C; De Savi, C; Donald, CS; Feron, LJ; Gingell, H; Glossop, SC; Hayter, BR; Hussain, S; Karoutchi, G; Lamont, SG; MacFaul, P; Moss, TA; Norman, RA; Pearson, SE; Rabow, AA; Tonge, M; Walker, GE; Weir, HM; Wilson, Z	1
Abadi, AH; Ahmed, NS; Elghazawy, NH; ElHady, AK; Engel, M; Hartmann, RW	1
Abrams, T; Baird, J; Burks, HE; Fekete, A; Hamann, LG; Kim, S; Kirby, CA; Lombardo, F; Loo, A; Lubicka, D; Macchi, K; McDonnell, DP; Mishina, Y; Norris, JD; Nunez, J; Peukert, S; Saran, C; Sun, Y; Thomsen, NM; Wang, C; Wang, J	1
Barrett, I; Carr, M; Fayne, D; Greene, LM; Keely, NO; Knox, AJS; Meegan, MJ; O'Boyle, NM; Twamley, B; Zisterer, DM	1
Capuzzi, SJ; Fisher, EG; García-Sastre, A; He, S; Li, H; Martínez-Romero, C; Muratov, EN; Qiu, X; Shinn, P; Sun, W; Tawa, G; Tropsha, A; Xu, M; Zheng, W; Zhu, W	1
Aparicio, A; Bonnefous, C; Brigham, D; Darimont, B; Douglas, K; Govek, S; Hager, JH; Heyman, R; Joseph, JD; Kahraman, M; Kaufman, J; Lai, A; Lee, K; Lu, N; Maheu, K; Nagasawa, J; Prudente, R; Qian, J; Rix, PJ; Sensintaffar, J; Shao, G; Smith, ND	1

Other Studies

36 other study(ies) available for 4-[1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol and tamoxifen

Article	Year
A molecular modeling study of the interactions between the antiestrogen drug tamoxifen and several derivatives, and the calcium-binding protein calmodulin. Journal of medicinal chemistry, 1992, Jul-24, Volume: 35, Issue:15 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Binding Sites; Calmodulin; Computer Simulation; Cyclic Nucleotide Phosphodiesterases, Type 1; Drug Interactions; Models, Molecular; Tamoxifen	1992
Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicated in estrogen receptor binding, protein kinase C activity, and MCF7 cell proliferation. Journal of medicinal chemistry, 1992, Feb-07, Volume: 35, Issue:3 Topics: Acrylonitrile; Animals; Antineoplastic Agents; Breast Neoplasms; Cell Division; Dose-Response Relationship, Drug; Estrogen Antagonists; Female; Humans; Multivariate Analysis; Protein Kinase C; Rats; Receptors, Estrogen; Stilbenes; Structure-Activity Relationship; Tumor Cells, Cultured	1992
Derivatives of tamoxifen. Dependence of antiestrogenicity on the 4-substituent. Journal of medicinal chemistry, 1989, Volume: 32, Issue:12 Topics: Animals; Cattle; Chemical Phenomena; Chemistry; Cytosol; Estrogen Antagonists; Female; Receptors, Estrogen; Tamoxifen; Tumor Cells, Cultured; Uterus	1989
Effect of triphenylacrylonitrile derivatives on estradiol-receptor binding and on human breast cancer cell growth. Journal of medicinal chemistry, 1989, Volume: 32, Issue:9 Topics: Animals; Breast Neoplasms; Cattle; Cell Division; Cell Line; Chemical Phenomena; Chemistry; Cytosol; Female; Growth Inhibitors; Humans; Isomerism; Mice; Nitriles; Rats; Receptors, Estradiol; Structure-Activity Relationship; Terphenyl Compounds; Tumor Cells, Cultured	1989
Hydroxy derivatives of tamoxifen. Journal of medicinal chemistry, 1985, Volume: 28, Issue:10 Topics: Binding, Competitive; Breast Neoplasms; Cell Division; Cell Line; Chemical Phenomena; Chemistry; Female; Humans; Hydroxylation; Receptors, Estrogen; Stereoisomerism; Structure-Activity Relationship; Tamoxifen	1985
Rationally designed analogues of tamoxifen with improved calmodulin antagonism. Journal of medicinal chemistry, 1995, Jan-20, Volume: 38, Issue:2 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Calmodulin; Cyclic Nucleotide Phosphodiesterases, Type 1; Drug Design; Models, Molecular; Structure-Activity Relationship; Tamoxifen	1995
Structure-activity relationships of selective estrogen receptor modulators: modifications to the 2-arylbenzothiophene core of raloxifene. Journal of medicinal chemistry, 1997, Jan-17, Volume: 40, Issue:2 Topics: Adenocarcinoma; Animals; Binding Sites; Bone and Bones; Breast Neoplasms; Cell Division; Cholesterol; Estrogen Antagonists; Female; Humans; Male; Organ Size; Ovariectomy; Piperidines; Raloxifene Hydrochloride; Rats; Rats, Sprague-Dawley; Receptors, Estrogen; Structure-Activity Relationship; Uterus	1997
Cytotoxicity and antiestrogenicity of a novel series of basic diphenylethylenes. Journal of medicinal chemistry, 1997, Mar-28, Volume: 40, Issue:7 Topics: Antineoplastic Agents; Cell Division; Crystallography, X-Ray; Estrogen Antagonists; Ethylenes; Humans; Magnetic Resonance Spectroscopy; Mass Spectrometry; Multivariate Analysis; Tumor Cells, Cultured	1997
Discovery and synthesis of [6-hydroxy-3-[4-[2-(1-piperidinyl)ethoxy]phenoxy]-2-(4-hydroxyphenyl)]b enzo[b]thiophene: a novel, highly potent, selective estrogen receptor modulator. Journal of medicinal chemistry, 1997, May-09, Volume: 40, Issue:10 Topics: Animals; Breast Neoplasms; Cell Division; Estrogen Antagonists; Female; Humans; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Structure; Piperidines; Raloxifene Hydrochloride; Rats; Rats, Sprague-Dawley; Receptors, Estrogen; Tumor Cells, Cultured	1997
(S)-(+)-4-[7-(2,2-dimethyl-1-oxopropoxy)-4-methyl-2-[4-[2-(1-piperidinyl)-ethoxy]phenyl]-2H-1-benzopyran-3-yl]-phenyl 2,2-dimethylpropanoate (EM-800): a highly potent, specific, and orally active nonsteroidal antiestrogen. Journal of medicinal chemistry, 1997, Jul-04, Volume: 40, Issue:14 Topics: Administration, Oral; Animals; Benzopyrans; Binding, Competitive; Breast Neoplasms; Cytosol; Diethylstilbestrol; Estradiol; Estrogen Antagonists; Female; Humans; Mice; Molecular Structure; Ovariectomy; Piperidines; Propionates; Raloxifene Hydrochloride; Receptors, Estrogen; Stereoisomerism; Structure-Activity Relationship; Uterus	1997
Synthesis and pharmacology of conformationally restricted raloxifene analogues: highly potent selective estrogen receptor modulators. Journal of medicinal chemistry, 1998, Apr-09, Volume: 41, Issue:8 Topics: Animals; Bone Density; Cell Division; Cholesterol; Estrogen Antagonists; Female; Gene Expression Regulation; HeLa Cells; Humans; Models, Molecular; Molecular Conformation; Naphthoquinones; Organ Size; Ovariectomy; Piperidines; Raloxifene Hydrochloride; Rats; Rats, Sprague-Dawley; Receptors, Estrogen; Structure-Activity Relationship; Transforming Growth Factor beta; Tumor Cells, Cultured; Uterus	1998
Antiestrogenically active 1,1,2-tris(4-hydroxyphenyl)alkenes without basic side chain: synthesis and biological activity. Journal of medicinal chemistry, 2003, Apr-10, Volume: 46, Issue:8 Topics: Animals; Antineoplastic Agents; Binding, Competitive; Breast Neoplasms; Cattle; Cytosol; Drug Screening Assays, Antitumor; Estrogen Receptor Modulators; Ethylenes; Female; Humans; Neoplasms, Hormone-Dependent; Phenols; Radioligand Assay; Receptors, Estrogen; Structure-Activity Relationship; Transcription, Genetic; Tumor Cells, Cultured; Uterus	2003
Estrogen receptor modulators: identification and structure-activity relationships of potent ERalpha-selective tetrahydroisoquinoline ligands. Journal of medicinal chemistry, 2003, Jul-03, Volume: 46, Issue:14 Topics: Administration, Oral; Animals; Binding Sites; Biological Availability; Cell Division; Crystallography, X-Ray; Estradiol; Estrogen Receptor alpha; Estrogen Receptor beta; Estrogen Receptor Modulators; Female; HeLa Cells; Humans; Isoquinolines; Ligands; Models, Molecular; Radioligand Assay; Raloxifene Hydrochloride; Rats; Receptors, Estrogen; Stereoisomerism; Structure-Activity Relationship; Transcription, Genetic; Tumor Cells, Cultured	2003
Interactions of tamoxifen, N-desmethyltamoxifen and 4-hydroxytamoxifen with P-glycoprotein and CYP3A. Biopharmaceutics & drug disposition, 2004, Volume: 25, Issue:7 Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Caco-2 Cells; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Humans; Tamoxifen	2004
Impact of induced fit on ligand binding to the androgen receptor: a multidimensional QSAR study to predict endocrine-disrupting effects of environmental chemicals. Journal of medicinal chemistry, 2005, Sep-08, Volume: 48, Issue:18 Topics: Benzhydryl Compounds; Binding Sites; Diethylstilbestrol; Endocrine System; Hydrocarbons, Chlorinated; Ligands; Models, Molecular; Molecular Conformation; Phenols; Phytoestrogens; Quantitative Structure-Activity Relationship; Receptors, Androgen; Testosterone; Thermodynamics; Xenobiotics	2005
Synthesis and preliminary biological evaluation of new carbon-11 labeled tetrahydroisoquinoline derivatives as SERM radioligands for PET imaging of ER expression in breast cancer. European journal of medicinal chemistry, 2008, Volume: 43, Issue:10 Topics: Breast Neoplasms; Carbon Radioisotopes; Cell Line, Tumor; Cell Proliferation; Drug Design; Gene Expression Regulation, Neoplastic; Humans; Ligands; Positron-Emission Tomography; Radiochemistry; Receptors, Estrogen; Selective Estrogen Receptor Modulators; Staining and Labeling; Tetrahydroisoquinolines	2008
Synthesis, biological evaluation, structural-activity relationship, and docking study for a series of benzoxepin-derived estrogen receptor modulators. Bioorganic & medicinal chemistry, 2008, Nov-01, Volume: 16, Issue:21 Topics: Benzoxepins; Cell Proliferation; Estrogen Receptor alpha; Estrogen Receptor beta; Estrogen Receptor Modulators; Female; Humans; Models, Molecular; Molecular Structure; Tumor Cells, Cultured	2008
Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness. Nature chemical biology, 2009, Volume: 5, Issue:2 Topics: Breast Neoplasms; Drug Design; Enzyme Inhibitors; Humans; Isoenzymes; Neoplasm Invasiveness; Phospholipase D	2009
Potent and selective steroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 7, an enzyme that catalyzes the reduction of the key hormones estrone and dihydrotestosterone. Journal of medicinal chemistry, 2009, Dec-10, Volume: 52, Issue:23 Topics: 17-Hydroxysteroid Dehydrogenases; Androstane-3,17-diol; Androstanes; Biocatalysis; Cell Line; Dihydrotestosterone; Enzyme Inhibitors; Estradiol; Estrone; Humans; Inhibitory Concentration 50; Oxidation-Reduction; Substrate Specificity	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
2-phenyl-1-[4-(2-piperidine-1-yl-ethoxy)benzyl]-1H-benzimidazoles as ligands for the estrogen receptor: synthesis and pharmacological evaluation. Bioorganic & medicinal chemistry, 2010, Jul-15, Volume: 18, Issue:14 Topics: Antineoplastic Agents; Benzimidazoles; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Estrogen Receptor beta; Female; Gene Expression Regulation, Neoplastic; Humans	2010
Effects of 7-O substitutions on estrogenic and anti-estrogenic activities of daidzein analogues in MCF-7 breast cancer cells. Journal of medicinal chemistry, 2010, Aug-26, Volume: 53, Issue:16 Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Estradiol; Estrogen Antagonists; Estrogen Receptor alpha; Estrogens; Female; Humans; Hydrophobic and Hydrophilic Interactions; Isoflavones; Mice; Mice, Nude; Models, Molecular; Receptors, Progesterone; Response Elements; Structure-Activity Relationship; Transcription, Genetic; Xenograft Model Antitumor Assays	2010
Biomimetic syntheses and antiproliferative activities of racemic, natural (-), and unnnatural (+) glyceollin I. Journal of medicinal chemistry, 2011, May-26, Volume: 54, Issue:10 Topics: Antineoplastic Agents; Biomimetics; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Chromatography, High Pressure Liquid; Drug Screening Assays, Antitumor; Female; Humans; Magnetic Resonance Spectroscopy; Male; Models, Chemical; Ovarian Neoplasms; Prostatic Neoplasms; Pterocarpans; Receptors, Estrogen; Stereoisomerism	2011
Locating the binding sites of anticancer tamoxifen and its metabolites 4-hydroxytamoxifen and endoxifen on bovine serum albumin. European journal of medicinal chemistry, 2011, Volume: 46, Issue:9 Topics: Antineoplastic Agents, Hormonal; Binding Sites; Circular Dichroism; Models, Molecular; Protein Structure, Secondary; Serum Albumin, Bovine; Spectrometry, Fluorescence; Spectroscopy, Fourier Transform Infrared; Tamoxifen	2011
Hydrophobic Interactions Improve Selectivity to ERα for Ben-zothiophene SERMs. ACS medicinal chemistry letters, 2012, Mar-08, Volume: 3, Issue:3 Topics:	2012
Bioactivation of the cancer chemopreventive agent tamoxifen to quinone methides by cytochrome P4502B6 and identification of the modified residue on the apoprotein. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Anticarcinogenic Agents; Antineoplastic Agents, Hormonal; Apoproteins; Aryl Hydrocarbon Hydroxylases; Biotransformation; Cytochrome P-450 CYP2B6; Glutathione; Humans; Hydroxylation; Indolequinones; Microsomes, Liver; Oxidoreductases, N-Demethylating; Tamoxifen	2012
Synthesis and biological evaluation of novel tamoxifen analogues. Bioorganic & medicinal chemistry, 2013, Jul-15, Volume: 21, Issue:14 Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Endometrial Neoplasms; Female; Humans; Molecular Structure; Receptors, Estrogen; Tamoxifen	2013
Boron-Based 4-Hydroxytamoxifen Bioisosteres for Treatment of de Novo Tamoxifen Resistant Breast Cancer. ACS medicinal chemistry letters, 2012, Apr-06, Volume: 3, Issue:5 Topics:	2012
Structure-activity relationship study of diphenylamine-based estrogen receptor (ER) antagonists. Bioorganic & medicinal chemistry, 2015, Feb-15, Volume: 23, Issue:4 Topics: Breast Neoplasms; Cell Proliferation; Diphenylamine; Estrogen Receptor alpha; Estrogen Receptor Antagonists; Female; Humans; MCF-7 Cells; Structure-Activity Relationship	2015
Identification of GDC-0810 (ARN-810), an Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) that Demonstrates Robust Activity in Tamoxifen-Resistant Breast Cancer Xenografts. Journal of medicinal chemistry, 2015, Jun-25, Volume: 58, Issue:12 Topics: Administration, Oral; Animals; Antineoplastic Agents; Breast; Breast Neoplasms; Cell Line, Tumor; Dogs; Drug Discovery; Drug Resistance, Neoplasm; Estrogen Receptor alpha; Female; Heterografts; Humans; Mice; Proteolysis; Rats; Selective Estrogen Receptor Modulators; Small Molecule Libraries; Tamoxifen	2015
Optimization of a Novel Binding Motif to (E)-3-(3,5-Difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)acrylic Acid (AZD9496), a Potent and Orally Bioavailable Selective Estrogen Receptor Downregu Journal of medicinal chemistry, 2015, Oct-22, Volume: 58, Issue:20 Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cinnamates; Clinical Trials, Phase I as Topic; Down-Regulation; Drug Design; Estrogen Antagonists; Estrogen Receptor Modulators; Female; Humans; Indoles; Injections, Intramuscular; X-Ray Diffraction	2015
Design and synthesis of novel tamoxifen analogues that avoid CYP2D6 metabolism. European journal of medicinal chemistry, 2016, Apr-13, Volume: 112 Topics: Antineoplastic Agents, Hormonal; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cytochrome P-450 CYP2D6; Esterification; Estrogen Receptor alpha; Female; Humans; MCF-7 Cells; Molecular Docking Simulation; Neoplasms; Tamoxifen	2016
Discovery of an Acrylic Acid Based Tetrahydroisoquinoline as an Orally Bioavailable Selective Estrogen Receptor Degrader for ERα+ Breast Cancer. Journal of medicinal chemistry, 2017, 04-13, Volume: 60, Issue:7 Topics: Acrylates; Administration, Oral; Animals; Antineoplastic Agents; Breast; Breast Neoplasms; Dogs; Drug Discovery; Estrogen Receptor alpha; Female; Humans; MCF-7 Cells; Mice, Inbred C57BL; Molecular Docking Simulation; Proteolysis; Tetrahydroisoquinolines	2017
Lead Optimization of Benzoxepin-Type Selective Estrogen Receptor (ER) Modulators and Downregulators with Subtype-Specific ERα and ERβ Activity. Journal of medicinal chemistry, 2018, 01-25, Volume: 61, Issue:2 Topics: Antineoplastic Agents; Benzoxepins; Crystallography, X-Ray; Estrogen Receptor alpha; Estrogen Receptor beta; Humans; Ligands; MCF-7 Cells; Models, Molecular; Molecular Docking Simulation; Proteolysis; Selective Estrogen Receptor Modulators; Structure-Activity Relationship	2018
Computer-Aided Discovery and Characterization of Novel Ebola Virus Inhibitors. Journal of medicinal chemistry, 2018, 04-26, Volume: 61, Issue:8 Topics: Animals; Antiviral Agents; Chlorocebus aethiops; Drug Discovery; Drug Evaluation, Preclinical; Ebolavirus; HeLa Cells; Humans; Molecular Structure; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Virus Internalization	2018
Identification of an Orally Bioavailable Chromene-Based Selective Estrogen Receptor Degrader (SERD) That Demonstrates Robust Activity in a Model of Tamoxifen-Resistant Breast Cancer. Journal of medicinal chemistry, 2018, 09-13, Volume: 61, Issue:17 Topics: Administration, Oral; Animals; Antineoplastic Agents; Benzopyrans; Breast Neoplasms; Cell Proliferation; Drug Resistance, Neoplasm; Estrogen Receptor alpha; Female; Humans; Mice; Rats; Selective Estrogen Receptor Modulators; Tumor Cells, Cultured; Xenograft Model Antitumor Assays	2018